Friday, May 4, 2012

BioFET-SIM Web Interface: Implementation and Two Applications

Martin submitted a new paper to PLoS ONE:

BioFET-SIM Web Interface: Implementation and Two Applications Martin R. Hediger, Jan H. Jensen, Luca De Vico. arXiv   biofetsim.org

The paper was submitted April 27 and deposited on arXiv the same day.

Abstract
We present a web interface for the BioFET-SIM program. The web interface allows to conveniently setup calculations based on the BioFET-SIM multiple charges model. As an illustration, two case studies are presented. In the first case, a generic peptide with opposite charges on both ends is inverted in orien- tation on a semiconducting nanowire surface leading to a corresponding change in sign of the computed sensitivity of the device. In the second case, the binding of an antibody/antigen complex on the nanowire surface is studied in terms of orientation and analyte/nanowire surface distance. We demonstrate how the BioFET-SIM web interface can aid in the understanding of experimental data and postulate alternative ways of antibody/antigen orientation on the nanowire surface.

Martin made a really nice screencast of the interface. 
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