Here's
a simple script for generating rotamers. It assumes the input geometry is reasonable and perturbs the dihedral angles of
n rotateable bonds by
\pm 120^\circ. It makes all
3^n combinations of dihedral angles but if that is larger than a user-defined cutoff it will pick a random subset. Rotateable bonds include alcohol, phenols, and primary amines, but also amide bonds. It doesn't know about equivalent atoms, so it will happily rotate a tert-butyl or trifluoromethyl group.

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Creative Commons Attribution 4.0
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