Saturday, February 17, 2018 a simple script to generate rotamers

Here's a simple script for generating rotamers. It assumes the input geometry is reasonable and perturbs the dihedral angles of $n$ rotateable bonds by $\pm 120^\circ$. It makes all $3^n$ combinations of dihedral angles but if that is larger than a user-defined cutoff it will pick a random subset. Rotateable bonds include alcohol, phenols, and primary amines, but also amide bonds.  It doesn't know about equivalent atoms, so it will happily rotate a tert-butyl or trifluoromethyl group.

This work is licensed under a Creative Commons Attribution 4.0

No comments: